Concise Guide to Hematology by Hillard M. Lazarus & Alvin H. Schmaier

Author:Hillard M. Lazarus & Alvin H. Schmaier
Language: eng
Format: epub
ISBN: 9783319978734
Publisher: Springer International Publishing

Genomic Microarray Testing

Advantages: Microarray technique employs thousand to million probes over the entire genome to detect genomic imbalances, such as gain or loss of relevant chromosome regions in tumor cells. Genomic microarray with single nucleotide polymorphism (SNP) probes also reveals copy-neutral loss of heterozygosity (CN-LOH). Microarray tests are particularly useful in revealing whole genomic abnormalities and CN-LOH features in solid tumors in FFPE preparations or in those without dividing cells. The analysis also defines a precise size of deletion or gain region and genes involved. Limitations: (1) Balanced chromosome translocations, inversions, or insertions cannot be detected. (2) The sensitivity of the test is approximately only 10–20%; therefore, it cannot reproducibly detect small clones below 20% of tumor content in a specimen.

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